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Microscopy

Microscopy

Optical technique measures intramolecular distances with angstrom precision

28 Oct 2024 Isabelle Dumé
Diagram showing distances between molecules measured in polyproline
Distance markers: Polyprolines are relatively stiff polypeptides that can be used as intramolecular “rulers” to demonstrate MINFLUX optical resolutions. This image shows optically measured distances in nanometres using chains of polyprolines 5 to 30 repeats long. The white ellipses at right show the measurement uncertainty in each position determination (2 sigma). (Courtesy: Steffen J. Sahl / Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany)
Physicists in Germany have used visible light to measure intramolecular distances smaller than 10 nm

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Isabelle Dumé is a contributing editor to Physics World
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